An Israeli soldier is the latest confirmed dead as a result of clashes on the country’s border with Gaza.
The news comes hours after the deaths of four Palestinians on Friday, three of whom were Hamas members and the fourth a civilian.
They are among more than 135, mostly unarmed, Palestinians killed by Israeli fire since border protests began at the end of March.
The United Nations has urged Hamas and Israel to “step back from the brink” as tensions between the two sides continue to flare.
The UN’s special coordinator for the Middle East peace process, Nickolay Mladenov, wrote on Twitter: “Everyone in Gaza needs to step back from the brink.
“Not next week. Not tomorrow. Right NOW! Those who want to provoke Palestinians and Israelis into another war must not succeed.”
Some 120 Palestinians were also injured on Friday.
The Israeli Defence Forces said it had launched a large attack on Hamas military targets on the Gaza Strip following “a severe shooting attack against IDF soldiers this afternoon”.
“Earlier today, IDF aircraft and tanks targeted military targets belonging to the Hamas terror organisation.
“The IDF views today’s attack and the hostile activity orchestrated by Hamas throughout the last months with great severity.
“Hamas chose to escalate the security situation and will bear the consequences for its actions. IDF troops are on high alert and will continue to operate in order to ensure the safety of Israeli civilians.”
The soldier was killed during “operational activity near the southern Gaza Strip”, they said.
“During the incident, a terrorist squad shot at IDF troops and the IDF soldier was severely injured. He later succumbed to his wounds.”
On Friday, Hamas vowed to continue its protests and the launching of incendiary devices towards Israel.
Khalil al-Hayya, a top Hamas leader, said: “The protests will remain, flaming and existing, and its tools will multiply and diversify, including kites, until our goals are achieved”.
The protests are largely prompted by the Israeli-Egyptian blockade, which was imposed after the militant group assumed control of Gaza in 2007.
The blockade has caused widespread economic hardship for many Palestinians.